Planning permission for the development was granted by Buckinghamshire Council following an application prepared and submitted by Carter Jonas on behalf of the trust.
Earlier this year, MTX Contracts secured a £9.8m contract to deliver the two-storey therapies and outpatients building, which will include consultation rooms, a rehabilitation gym and therapy spaces.
The wider project team includes architect Gilling Dodd, alongside Cotswold Archaeology, NoiseAir Limited, Steven A. Hunt & Associates, iteriad, Evoke, Alan Johnston Partnership and Servtron.
The new building will replace an existing prefabricated therapies facility and has been designed to meet the requirements of a modern healthcare environment.
It will accommodate musculoskeletal (MSK), hand therapy and dietetics services, alongside outpatient facilities, clinical treatment areas, administrative accommodation and staff support spaces.
Stoke Mandeville Hospital is a major healthcare provider for Buckinghamshire, delivering emergency and specialist services including accident and emergency, maternity care, critical care and spinal injuries treatment.